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Sicherheit, Verträglichkeit und Wirksamkeit von oral verabreichten Cannabinoiden bei MS

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Englischer Titel

Review/Studie

Teilnehmer:

16

Darreichungsform:

x

Applikation:

Oral

Autoren:

Killestein J, Hoogervorst EL, Reif M, Kalkers NF, Van Loenen AC, Staats PG, Gorter RW, Uitdehaag BM, Polman CH

Fundstelle:

https://pubmed.ncbi.nlm.nih.gov/12011290/

Abstract

The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse events were more common with plant-extract treatment. Compared with placebo, neither THC nor plant-extract treatment reduced spasticity. Both THC and plant-extract treatment worsened the participant’s global impression.

 
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